Abstract

Methicillin Resistant Staphylococcus Aureus and Their Antibiotic Resistance Pattern Among Clinical Samples in a Tertiary Care Hospital in Rural South India

Author(s): Savitha P.1*, Swetha K. and Beena P. M.3

Background- Methicillin Resistant Staphylococcus aureus (MRSA) is an important causative agent of infections with multiple drug resistance. They are also one of the important organisms causing nosocomial infections. Objective-To study the prevalence of MRSA infections among different clinical conditions, To know the antibiotic susceptibility patterns of the isolates. Also to know the changes in the antibiotic susceptibility patterns over the years Materials and Methods-This study was done using various clinical samples, which included Pus, Blood, Urine, Sputum and synovial fluid obtained from patients. Staphylococcus Aureus isolated from the above specimens were identified by Tube coagulase, Urease production and Mannitol fermentation test according to the Central Laboratory Standards (CLSI) guidelines Results-Of the isolates 318 (30.57%) were community acquired and 140 (69.43%) were hospital acquired strains. There was a change noted in the antibiotic sensitivity pattern, for the first two years of the study we isolated organism which were more sensitive to chloramphenicol but later on the sensitivity to chloramphenicol decreased but at the same time increase in tetracycline sensitivity was observed. Conclusion- Staphylococcal infections especially MRSA poses a great health threat to all individuals including patients and health care workers. Hence there is a strict need for the development of antibiotic policy for each and every clinical set up. Most of the wound infections with MRSA can be treated with local dressing rather than systemic antibiotics

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