Abstract

Potentiometric Study of Complexation of Gentamicin with Mn (II) Metal Ions

Author(s): Archana Shukla1*, M. K.Singh2&A. K. Pandey3

Most of the transition metals form complexes. There are different kinds of ligands used for complexation. Metals can play an important role in modifying the pharmacological properties of known drugs after coordinating with it .The stability constants for the metal complexes are widely used in various fields such as biolog-ical processes, analytical processes, separations techniques, pharmaceuticals etc. The present work consists of the determination of the stability constant of Gentamicin antibiotics with bivalent metal ion Mn (II) in 50% (v/v )etha-nol-water medium at three different temperatures (30,35and 40°C) and ionic strength 0.1 M (NaNO3). It is ob-served that a Mn (II) and Gentamicin antibiotic forms 1:1and 1:2 complexes. The thermodynamic parameters Gibbs free energy change (ΔG), enthalpy change (ΔH) and entropy change(ΔS) were also calculated from stability constants value at three temperatures .All the thermodynamic parameters were found to be negative.

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