Abstract

Synthesis, Characterization and Biological Evaluation of 3,7-substituted-1[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]pyrido[2,3-b]pyrazin-2(1H)-onederivatives

Author(s): S.S.Dhok & S.E.Bhandarkar

Ethyl-(3,7-substituted-2-oxo-pyrido-[2,3-b]-pyrazin-1-(2H)-yl)acetate were synthesized from 3,7-substituted-2-oxo-pyrido-[2,3-b]-pyrazin-1-(2H)-yl on condensation with ethyl chloroacetate.Ethyl(3,7-substituted-2-oxo-pyrido-[2,3-b]-pyrazin-1-(2H)-yl)-acetohydrazide were synthesised from the reaction ofethyl(3,7-substituted-2-oxo-pyrido-[2,3-b]-pyrazin-1-(2H)-yl)-acetatewith hydrazine hydrate. The compounds of 3,7-substituted-1-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)-methyl]-pyrido-[2,3-b]-pyrazin-2-(1H)-one were synthesised from ethyl(3,7-substituted-2-oxo-pyrido-[2,3-b]-pyrazin-1-(2H)-yl)-acetohydrazideon cyclisation with carbon disulphide in methanolic potassium hydroxide .The isolated products were recrystallizedfrom chloroform.The compounds thus synthesized have been characterized by chemical,physical, andspectral data.All of these titled synthesized com-pounds have been examined forantimicrobial study and arefound to possesses very good antimicrobial activities.

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