Abstract

Synthesis, Characterization and Biological Study of Hydantoin Derivatives

Various hydantoin derivatives were synthesized in moderate to excellent yield. Aurone derivatives and ureadissolved in ethanol then 10% KOH was added, shake well & reflux for 3 hrs. Allow the reaction mixture to cool. It was then decomposed in acedified dil HCl with constant stirring,solid thus obtained was washed with NaHCO3dried and recrystalised from ethanol to get hydantoin derivative. To check purity of compound Thin Layer Chromatography was used. The synthesized aurane derivatives were characterized by IR Spectroscopy, 1H NMR Spectroscopy and elemental analysis. All Newly synthesized derivatives of hydantoin were screened for their biologi-cal study i.e. antifungal and antimicrobialstudy and all newly synthesized substituted hydantoin showsan excellent antifungal and antimicrobial activity.

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