Abstract

The Nephrotoxic Potential of Stevia in Chicken Embryo Model

Author(s): Mahadi Jahanbakhsh1, Reza Sayrafi2 , Parisa Sadighara

Stevioside, a plentiful component of Stevia rebaudiana leaves, has become well-known for its intense sweetness is used as a non-caloric sweetener in many countries. The aim of this study was to investigate nephrotoxicity of stevia sweeteners on chicken embryo. The 10,100 and 1000PPM of stevia doses was injected into into the egg yolk on the day 4 of incubation. The experiment was terminated on the day 21 of incubation, then, the kidney sample tissues were collected. The oxidative stress parameters and kidney parameters in serum were measured and compared in the groups. It is however known that the increase of some oxidative parameters. Serum parameters show that there was an increase in the levels of creatinine. Overall, our study demonstrated stevioside induced nephrotoxicity in high doses and it is likely to be mediated through oxidative stress mechanisms.

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